Escherichia coli infection, intimin, and Toll-like receptors
نویسندگان
چکیده
The recognition of PAMPs by TLRs initiates the induction of inflammatory responses in the host cells through activation of signal transduction pathways mediated by transcription factor (nuclear factor-κB, NF-κB). Considering TLRs expressed in human cells TLR1, TLR2, TLR4, TLR5, and TLR6 are positioned near trans-membrane domains and are vital to the defense response of cells against external pathogens.
منابع مشابه
A DNA Vaccine against Escherichia coli O157:H7
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Intimin is a bacterial outer membrane protein required for intimate attachment of enterohemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC) to mammalian cells. beta1-chain integrins have been proposed as candidate receptors for intimin. We found that binding of mammalian cells to immobilized intimin was not detectable unless mammalian cells were preinfected with EPEC or EHEC. beta...
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